We (Kimata group) are an independent research unit in the Laboratory of Microbial Interaction, Division of Biological Science, Nara Institute of Science and Technology. Our mission is to elucidate the molecular mechanism and the physiological significance of the endoplasmic reticulum (ER)-stress response using yeast cells as a model organism. Our findings will be employed for molecular breeding of new industrially beneficial yeast strains.
The ER stress sensor Ire1 clusters and forms foci upon ER stress.
Fluorescent-microscopic image of yeast Saccharomyces cerevisiae cells. Green: Immunofluorescent staining of HA-epitope-tagged Ire1 (FITC); Red: Immunofluorescent staining of ER-located molecular chaperone BiP (Cy5); Blue: Nuclei (DNA stained by DAPI).