Original Research papers

56. Hata T, Ishiwata-Kimata Y, Kimata Y
Self-association status-dependent inactivation of the endoplasmic reticulum stress sensor Ire1 by C-terminal tagging with artificial peptides
Biosci. Biotechnol. Biochem. in press
55. Hata T, Ishiwata-Kimata Y, Kimata Y
Induction of the unfolded protein response at high temperature in Saccharomyces cerevisiae
Int. J. Mol. Sci. Vol.23, 1669, 2022
54. Ishiwata-Kimata Y, Le QG, Kimata Y
Induction and aggravation of the endoplasmic-reticulum stress by membrane-lipid metabolic intermediate phosphatidyl-N-monomethylethanolamine
Front. Cell Dev. Biol. Vol.9, 743018, 2022
53. Phuong TH, Ishiwata-Kimata Y, Nishi Y, Oguchi N, Takagi H, Kimata Y
"Aeration mitigates endoplasmic reticulum stress in Saccharomyces cerevisiae even without mitochondrial respiration."
Microb. Cell Vol.8, 77-86, 2021
52. Le QG, Ishiwata-Kimata Y, Phuong TH, Fukunaka S, Kohno K, Kimata Y
"The ADP-binding kinase region of Ire1 directly contributes to its responsiveness to endoplasmic reticulum stress."
Sci. Rep. Vol.11 4506, 2021
51. Fauzee YNBM, Taniguchi N, Ishiwata-Kimata Y, Takagi H, Kimata Y
"The unfolded protein response in Pichia pastoris without external stressing stimuli."
FEMS Yeast Res. Vol.20 foaa053, 2020
50. Tran DM, Ishiwata-Kimata Y, Mai TC, Kubo M, Kimata Y.
“The unfolded protein response alongside the diauxic shift of yeast cells and its involvement in mitochondria enlargement.”
Sci. Rep. Vol. 9 12780, 2019
49. Mai TC, Ishiwata-Kimata Y, Le QG, Kido H, Kimata Y.
“Dispersion of Endoplasmic Reticulum-associated Compartments by 4-phenyl Butyric Acid in Yeast Cells.”
Cell. Struct. Funct. Vol. 44, 173-182, 2019
48. Nguyen PTM, Ishiwata-Kimata Y, Kimata Y.
“Monitoring ADP/ATP ratio in yeast cells using the fluorescent-protein reporter PercevalHR.”
Biosci. Biotechnol. Biochem. Vol. 83, 824-828, 2019
47. Tran DM, Takagi H, Kimata Y.
“Categorization of endoplasmic reticulum stress as accumulation of unfolded proteins or membrane lipid aberrancy using yeast Ire1 mutants.”
Biosci. Biotechnol. Biochem. Vol. 83, 326-329, 2019
46. Mai TC, Munakata T, Tran DM, Takagi H, Kimata Y.
“A chimeric mutant analysis in yeast cells suggests BiP independent regulation of the mammalian endoplasmic reticulum-stress sensor IRE1α.”
Biosci. Biotechnol. Biochem. Vol. 82, 1527-1530, 2018
45. Mai CT, Le QG, Ishiwata-Kimata Y, Takagi H, Kohno K, Kimata Y.
“4-Phenylbutyrate suppresses the unfolded protein response without restoring protein folding in Saccharomyces cerevisiae.”
FEMS Yeast Res. Vol. 18, foy016, 2018
44. Itooka K, Takahashi K, Kimata Y, Izawa S.
“Cold atmospheric pressure plasma causes protein denaturation and endoplasmic reticulum stress in Saccharomyces cerevisiae.”
Appl. Microbiol. Biotechnol. Vol. 102, 2279-2288, 2018
43. Kawazoe N, Kimata Y, Izawa S.
“Acetic Acid Causes Endoplasmic Reticulum Stress and Induces the Unfolded Protein Response in Saccharomyces cerevisiae.”
Front. Microbiol. Vol. 8, 1192, 2017
42. Le QG, Ishiwata-Kimata Y, Kohno K, Kimata Y.
“Cadmium impairs protein folding in the endoplasmic reticulum and induces the unfolded protein response.”
FEMS Yeast Res. Vol.16, fow049, 2016
41. Mathuranyanon R, Tsukamoto T, Takeuchi A, Ishiwata-Kimata Y, Tsuchiya Y, Kohno K, Kimata Y.
“Tight regulation of the unfolded protein sensor Ire1 by its intramolecularly antagonizing subdomain.”
J. Cell Sci. Vol.128, 1762-172, 2015
40. Mochizuki T, Kimata Y, Uemura S, Abe F.
“Retention of chimeric Tat2-Gap1 permease in the endoplasmic reticulum induces unfolded protein response in Saccharomyces cerevisiae.”
FEMS Yeast Res. Vol.15, fov044, 2015
39. Miyagawa D, Ishiwata-Kimata Y, Kohno K, Kimata Y
“Ethanol stress impairs protein folding in the endoplasmic reticulum and activates Ire1 in Saccharomyces cerevisiae.”
Biosci. Biotechnol. Biochem. Vol.78,1389-1391, 2014
38. Ishiwata-Kimata Y, Yamamoto YH, Takizawa K, Kohno K, Kimata Y
F-actin and a type-II myosin are required for efficient clustering of the ER stress sensor Ire1.
Cell Struct. Funct. Vol.38, 135-143. 2013
37. Ishiwata-Kimata Y, Promlek T, Kohno K, Kimata Y
“BiP-bound and nonclustered mode of Ire1 evokes a weak but sustained unfolded protein response.”
Genes Cells Vol.18, 288-301, 2013
36. Nguyen TSL, Kohno K, Kimata Y
“Zinc depletion activates the endoplasmic reticulum-stress sensor Ire1 via pleiotropic mechanisms.”
Biosci. Biotechnol. Biochem. Vol. 77, 1337-1339, 2013
35. Promlek T, Ishiwata-Kimata Y, Shido M, Sakuramoto M, Kohno K, Kimata Y
“Membrane aberrancy and unfolded aroteins activate the endoplasmic reticulum-stress sensor Ire1 by different manners.”
Mol. Biol. Cell Vol.22, 3520-3532, 2011
34. Yanagitani K, Kimata Y, Kadokura H, Kohno K
“Translational pausing ensures membrane targeting and cytoplasmic splicing of XBP1u mRNA.”
Science Vol.331, 586-589, 2011
33. Yamamoto YH, Kimura T, Momohara S, Takeuchi M, Tani T, Kimata Y, Kadokura H, Kohno K
“A novel ER J-protein DNAJB12 accelerates ER-associated degradation of membrane proteins including CFTR.”
Cell Struct. Funct. Vol.35, 107-116, 2010
32. Yanagitani K, Imagawa Y, Iwawaki T, Hosoda A, Saito M, Kimata Y, Kohno K
“Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA.”
Mol. Cell Vol.34, 191-200, 2009
31. Oikawa D, Kimata Y, Kohno K, Iwawaki T
“Activation of mammalian IRE1alpha upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins.”
Exp. Cell Res. Vol. 315, 2496-2504. 2009
30. Takeuchi M, Kimata Y, Kohno K
“Saccharomyces cerevisiae Rot1 Is an Essential Molecular Chaperone in the Endoplasmic Reticulum.”
Mol. Biol. Cell Vol.19, 3514-3525, 2008
29. Kimata Y, Ishiwata-Kimata Y, Ito T, Hirata A, Suzuki T, Oikawa D, Takeuchi M, Kohno K
“Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteins.”
J. Cell Biol. Vol.179, 75-86, 2007
28. Kimura Y, Saito M, Kimata Y, Kohno K
“Transgenic mice expressing a fully nontoxic diphtheria toxin mutant, not CRM197 mutant, acquire immune tolerance against diphtheria toxin.”
J. Biochem. Vol.142, 105-112, 2007
27. Oikawa D, Kimata Y, Kohno K
“Self-association and BiP dissociation are not sufficient for activation of the ER stress sensor Ire1.”
J. Cell Sci. Vol.120, 1681-1688, 2007
26. Takeuchi M, Kimata Y, Hirata A, Oka M, Kohno K
“Saccharomyces cerevisiae Rot1p Is an ER-Localized Membrane Protein That May Function with BiP/Kar2p in Protein Folding.”
J. Biochem. Vol.139, 597-605, 2006
25. Kimata Y, Ishiwata-Kimata Y, Yamada S, Kohno K
“Yeast unfolded protein response pathway regulates expression of genes for anti-oxidative stress and for cell surface proteins.”
Genes Cells. Vol.11, 59-69, 2006
24. Oikawa D, Kimata Y, Takeuchi M, Kohno K
“An essential dimer-forming subregion of the endoplasmic reticulum stress sensor Ire1.”
Biochem J. Vol.391, 135-142, 2005
23. Kimata Y, Oikawa D, Shimizu Y, Ishiwata-Kimata Y, Kohno, K
“A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1.”
J. Cell Biol. Vol.167, 445-456, 2004
22. Kimata Y, Kimata YI, Shimizu Y, Abe H, Farcasanu IC, Takeuchi M, Rose MD, Kohno K
“Genetic evidence for a role of BiP/Kar2 that regulates Ire1 in response to accumulation of unfolded proteins.”
Mol. Biol. Cell Vol.14, 2559-2569, 2003
21. Ohdate H, Lim CR, Kokubo T, Matsubara K, Kimata Y, Kohno K
“Impairment of the DNA binding activity of the TATA-binding protein renders the transcriptional function of Rvb2p/Tih2p, the yeast RuvB-like protein, essential for cell growth.”
J. Biol. Chem. Vol.278, 14647-14656, 2003
20. Hosoda A, Kimata Y, Tsuru A, Kohno K
“JPDI, a novel endoplasmic reticulum-resident protein containing both a BiP-interacting J-domain and thioredoxin-like motifs.”
J. Biol. Chem. Vol.278, 2669-2676 2003
19. Fujioka Y, Kimata Y, Nomaguchi K, Watanabe K, Kohno K
“Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5/SMC6 complex involved in DNA repair.”
J. Biol. Chem. Vol.277, 21585-21591, 2002
18. Okushima Y, Koizumi N, Yamaguchi Y, Kimata Y, Kohno K, Sano H
“Isolation and Characterization of a Putative Transducer of Endoplasmic Reticulum Stress in Oryza sativa.”
Plant Cell Physiol. Vol.43, 532-539, 2002
17. Koizumi N, Martinez I, Kimata Y, Kohno K, Sano H, Chrispeels MJ
“Molecular characterization of two Arabidopsis Ire1 homologs, endoplasmic reticulum located transmembrane protein kinases.”
Plant Physiol. Vol.127, 949-962, 2001
16. Saito M, Iwawaki T, Taya C, Yonekawa H, Noda M, Inui Y, Mekada E, Kimata Y, Tsuru A, Kohno K
“Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice.”
Nature Biotechnol. Vol.19, 746-750, 2001
15. Iwawaki T, Hosoda A, Okuda T, Kamigori Y, Nomura-Furuwatari C, Kimata Y, Tsuru A, Kohno K
“Translation control by ER transmembrane kinase/ribonuclease IRE1 under ER stress.”
Nature Cell Biol. Vol.3, 158-164, 2001
14. Kimata Y, Ooboki K, Nomura-Furuwatari C, Hosoda A, Tsuru A, Kohno K
“Identification of a novel mammalian endoplasmic reticulum-resident KDEL protein using an EST database motif search.”
Gene Vol.261, 321-327, 2000
13. Yoshizawa F, Miura Y, Tsurumaru K, Kimata Y, Yagasaki K, Funabiki R
“Elongation factor 2 in the liver and skeletal muscle of mice is decreased by starvation.”
Biosci. Biotechnol. Biochem. Vol.64, 2482-2485, 2000
12. Okamura K, Kimata Y, Higashio H, Tsuru A, Kohno K
“Dissociation of Kar2p/BiP from an endoplasmic reticulum sensory molecule, Ire1p, triggers unfolded protein response in yeast.”
Biochem. Biophys. Res. Commun. Vol.279, 445-450, 2000
11. Lim CR, Kimata Y, Ohdate H, Kokubo T, Kikuchi N, Horigome T, Kohno K
“The Saccharomyces cerevisiae RuvB-like protein, Tih2p is required for cell cycle progression.”
J. Biol. Chem. Vol.275, 22409-22417, 2000
10. Higashio H, Kimata Y, Kiriyama T, Hirata A, Kohno K
“Sfb2p, a yeast protein related to Sec24p, can function as a constituent of COPII coats required for vesicle budding from the endoplasmic reticulum.”
J. Biol. Chem. Vol.275, 17900-17908, 2000
9. Kimata Y, Higashio H, Kohno K
“Impaired proteasome function rescues thermosensitivity of yeast cells lacking the coatomer subunit epsilon-COP.”
J. Biol. Chem. Vol.275, 10655-10660, 2000
8. Kimata Y, Lim CR, Kiriyama T, Nara A, Hirata A, Kohno K
“Mutation of the yeast epsilon-COP gene ANU2 causes abnormal nuclear morphology and defects in intracellular vesicular transport.”
Cell Struct. Funct. Vol.24, 197-208, 1999
7. Oka M, Nakai M, Endo T, Lim CR, Kimata Y, Kohno K
“Loss of Hsp70-Hsp40 chaperone activity causes abnormal nuclear distribution and aberrant microtubule formation in M-phase of Saccharomyces cerevisiae.”
J. Biol. Chem. Vol.273, 29727-29737, 1998
6. Kimata Y, Iwaki M, Lim CR, Kohno K
“A novel mutation which enhances the fluorescence of green fluorescent protein at high temperatures.”
Biochem. Biophys. Res. Commun. Vol.232, 69-73, 1997
5. Oka M, Kimata Y, Mori K, Kohno K
“Saccharomyces cerevisiae KAR2 (BiP) gene expression is induced by loss of cytosolic HSP70/Ssa1p through a heat shock element-mediated pathway.”
J. Biochem. Vol.121, 578-584, 1997
4. Lim CR, Kimata Y, Oka M, Nomaguchi K, Kohno K
“Thermosensitivity of green fluorescent protein fluorescence utilized to reveal novel nuclear-like compartments in a mutant nucleoporin NSP1.” 
J. Biochem. Vol.118, 13-17 1995
3. Kimata Y, Kohno K
“Elongation factor 2 mutants deficient in diphthamide formation show temperature-sensitive cell growth.”
J. Biol. Chem. Vol.269, 13497-134501 1994
2. Kimata Y, Harashima S, Kohno K
“Expression of non-ADP-ribosylatable, diphtheria toxin-resistant elongation factor 2 in Saccharomyces cerevisiae.”
Biochem. Biophys. Res. Commun. Vol.191, 1145-1151 1993
1. Masui M, Tsuchida K, Kimata Y, Ozaki S
“Epoxidation catalyzed by manganese(III) tetraphenylporphyrin chloride using dioxygen activated by a novel system containing N-hydroxyphthalimide and styrene.”
Chem. Pharm. Bull. Vol.35, 3078-3081, 1987
Reviews and Book Chapters
8. Le QG, Kimata Y.
"Multiple ways for stress sensing and regulation of the endoplasmic reticulum-stress sensors."
Cell Struct. Funct. In press
7. Ishiwata-Kimata Y, Le QG, Kimata Y.
“Stress-sensing and regulatory mechanism of the endoplasmic-stress sensors Ire1 and PERK.”
Endoplasmic Reticulum Stress in Diseases Vol. 5, 1-10, 2018
6. Tran DM, Kimata Y.
“The unfolded protein response of yeast Saccharomyces cerevisiae and other organisms.”
Plant Morphology Vol. 30, 15-24, 2018
5. Kimata Y, Nguyen PTM, Kohno K
“Response and cytoprotective mechanisms against proteotoxic stress in yeast and fungi.”
in Stress Response Mechanisms in Fungi -Theoretical and Practical Aspects- (Book) pp. 161-188, Springer
4. Oikawa D, Kimata Y
“Experimental approaches for elucidation of stress-sensing mechanisms of the Ire1 family proteins.”
Methods Enzymol. Vol.490, 195-216, 2011
3. Kimata Y, Kohno K
“Endoplasmic reticulum stress-sensing mechanisms in yeast and mammalian cellsh
Curr. Opp. Cell. Biol. Vol.23, 135-142, 2011
2. Takeuchi M, Kimata Y, Kohno K
“Causal links between protein folding in the ER and events along the secretory pathway.”
Autophagy Vol.2, 323-324, 2006
1. Kimata Y, Lim CR, Kohno K
“S147P green fluorescent protein: a less thermosensitive green fluorescent protein variant.”
Methods Enzymol. Vol.302, 373-378, 1999